The Huskies pulled away with 10 minutes left in the contest, going on a 16-2 run over six minutes.
The Huskies shook off an uneven start and dominated the final 30 minutes of the game, ending the regular season on a three-game winning streak as the team prepares for postseason play.
This is the first time Washington has beat the Ducks since 2019 and the first time they have beaten them at home since 2015.
The Washington men's basketball team fell to UCLA 77-66 in the Monday night make-up contest. It was a back-and-forth game until the second half when the Bruins (21-6, 13-5) were able to pull away.
Washington State cut the lead to three with under a minute remaining, but the Huskies executed a picture-perfect press break that led to a thunderous dunk from Matthews Jr. and a roar from the home crowd. The emotional, come-from-behind rivalry win had the Huskies feeling confident heading into a big stretch on the schedule.